Validation of a modified QuEChERS method for the extraction of multiple classes of pharmaceuticals from soils

Abstract Background The quick, easy, cheap, effective, rugged, and safe (QuEChERS) method can be employed for multi-residue analyses instead of traditional extraction methods due to its advantages in terms time required equipment. A modified version the QuEChERS has been developed quantifying eight pharmaceuticals belonging different classes three real soils with chemical properties. Firstly, have polluted all contaminants recoveries were determined by liquid chromatography tandem–mass spectrometry. Due similar from soils, validation carried out only on a soil determining linearity, recovery, precision, limit detection (LOD) quantification (LOQ) values. matrix-matched calibration adopted order avoid matrix effect levels fortification (50, 100 500 µg L ?1 ) used. Results recovery pharmaceuticals, exception tetracycline, any was between 72 113%. In procedure, fortified samples ranged 80 99%, relative standard deviations 1.2 11.8%, LOQ 20 36.9 ?g kg . Conclusion results present study confirmed validity range 50–500 Graphical